Each computer where the common language runtime is installed has a machine-wide code cache called the global assembly cache. The global assembly cache stores assemblies that are to be shared by several applications on the computer. This area is typically the folder under windows or winnt in the machine.
All the assemblies that need to be shared across applications need to be done thr ough the Global assembly Cache only. However it is not necessary to install assemblies into the global assembly cache to make them accessible to COM interop or unmanaged code.